Targeted Tracer Fate Association Study (TTFAS) is an exclusive service offered by SiDMAP.
It determines associations among ~440 pathway functions in each sample using a single 13C-glucose or 13C- palmitate tracer.¬† It is applied in in vitro, in vivo, preclinical, investigational and human studies and it reveals how homeostasis responds to a challenge.
Its main advantage is the visualization of System-wide enzyme specific substrate-product relationships and response to drug effects while offering flux driven surrogate (mechanistic) biomarkers of drug responsive multiple enzyme reactions.¬† TTFAS requires administration of the harmless tracer with multiple drug dosing and/or time points to establish associations.
TTFAS targets common, abundant metabolic products and their isotopomers without the need to determine unknown products or use annotations during data delivery and interpretations.
A Targeted Tracer Fate Association Study provides commanding discovery, diagnostics and System biology tools in the hands of biochemist physicians.¬† With experience it aids all aspects of translational research.¬† Isotopomer associations require informatics tools that are readily available through SiDMAP.